Drug General Information
Drug ID	D0L8RG
Former ID	DIB005386
Drug Name	CI-986
Drug Type	Small molecular drug
Indication	Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06]		Terminated	[525669]
Company	Parke-Davis & Co
Structure		Download 2D MOL 3D MOL
Formula	C21H35N3O2S2
Canonical SMILES	c1(sc(=S)[nH]n1)c1c(c(c(cc1)C(C)(C)C)[O-])C(C)(C)C.[N+]<br />(CCO)(C)(C)C
CAS Number	CAS 130116-16-4
PubChem Compound ID	3037017
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Modulator	[525669]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 525669	Role of leukotrienes on coronary vasoconstriction in isolated hearts of arthritic rats: effect of in vivo treatment with CI-986, a dual inhibitor of cyclooxygenase and lipoxygenase. Pharmacology. 2000 Jan;60(1):41-6.
Ref 525669	Role of leukotrienes on coronary vasoconstriction in isolated hearts of arthritic rats: effect of in vivo treatment with CI-986, a dual inhibitor of cyclooxygenase and lipoxygenase. Pharmacology. 2000 Jan;60(1):41-6.

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