Drug Information

Drug General Information
Drug ID
D0L8QQ
Former ID
DNC003711
Drug Name
VELNACRINE
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Discontinued in Phase 3 [527051]
Structure
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2D MOL

3D MOL
Formula
C13H14N2O
Canonical SMILES
C1CC(C2=C(C3=CC=CC=C3N=C2C1)N)O
InChI
1S/C13H14N2O/c14-13-8-4-1-2-5-9(8)15-10-6-3-7-11(16)12(10)13/h1-2,4-5,11,16H,3,6-7H2,(H2,14,15)
InChIKey
HLVVITIHAZBPKB-UHFFFAOYSA-N
PubChem Compound ID
3655
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [551238]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 527051Velnacrine for Alzheimer's disease. Cochrane Database Syst Rev. 2004;(2):CD004748.
Ref 551238Synthesis and biological activity of putative mono-hydroxylated metabolites of velnacrine, Bioorg. Med. Chem. Lett. 2(8):865-870 (1992).

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