Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0L8QQ
|
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| Former ID |
DNC003711
|
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| Drug Name |
VELNACRINE
|
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| Drug Type |
Small molecular drug
|
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| Indication | Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] | Discontinued in Phase 3 | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C13H14N2O
|
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| Canonical SMILES |
C1CC(C2=C(C3=CC=CC=C3N=C2C1)N)O
|
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| InChI |
1S/C13H14N2O/c14-13-8-4-1-2-5-9(8)15-10-6-3-7-11(16)12(10)13/h1-2,4-5,11,16H,3,6-7H2,(H2,14,15)
|
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| InChIKey |
HLVVITIHAZBPKB-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Acetylcholinesterase | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Glycerophospholipid metabolism | ||||
| Cholinergic synapse | |||||
| PANTHER Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | ||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
| Nicotinic acetylcholine receptor signaling pathway | |||||
| Pathway Interaction Database | ATF-2 transcription factor network | ||||
| PathWhiz Pathway | Phospholipid Biosynthesis | ||||
| WikiPathways | Monoamine Transport | ||||
| Biogenic Amine Synthesis | |||||
| Acetylcholine Synthesis | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| References | |||||
| REF 1 | Velnacrine for Alzheimer's disease. Cochrane Database Syst Rev. 2004;(2):CD004748. | ||||
| REF 2 | Synthesis and biological activity of putative mono-hydroxylated metabolites of velnacrine, Bioorg. Med. Chem. Lett. 2(8):865-870 (1992). | ||||
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