Drug Information

Drug General Information
Drug ID
D0L8PI
Former ID
DNC001307
Drug Name
SCH-23390
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543325]
Structure
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2D MOL

3D MOL
Formula
C17H18ClNO
InChI
InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m0/s1
InChIKey
GOTMKOSCLKVOGG-HNNXBMFYSA-N
CAS Number
CAS 87075-17-0
PubChem Compound ID
6603800
PubChem Substance ID
11111023, 43223595, 47805516, 47954440, 48105158, 48253929, 79039251, 114636936, 135651024, 136350220, 160677131, 224832001, 236328371
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Antagonist [537186]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
References
Ref 543325(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 956).
Ref 537186Dopamine modulates effort-based decision making in rats. Behav Neurosci. 2009 Apr;123(2):242-51.

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