Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0L8MO
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| Former ID |
DIB003461
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| Drug Name |
ME-3407
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| Synonyms |
EF-4040; 2-(Butoxycarbonylmethylsulfinyl)thiazolo[5,4-b]pyridine; 2-(Thiazolo[5,4-b]pyridin-2-ylsulfinyl)acetic acid butyl ester
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| Drug Type |
Small molecular drug
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| Indication | Duodenal ulcers [ICD10:K25-K27] | Phase 2 | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C12H14N2O3S2
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| Canonical SMILES |
CCCCOC(=O)CS(=O)C1=NC2=C(S1)N=CC=C2
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| InChI |
1S/C12H14N2O3S2/c1-2-3-7-17-10(15)8-19(16)12-14-9-5-4-6-13-11(9)18-12/h4-6H,2-3,7-8H2,1H3
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| InChIKey |
BUXNKFNNJJTLOS-UHFFFAOYSA-N
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| CAS Number |
CAS 133903-90-9
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Myosin light chain kinase, smooth muscle and non-muscle isozymes | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cGMP-PKG signaling pathway | |||||
| Vascular smooth muscle contraction | |||||
| Focal adhesion | |||||
| Platelet activation | |||||
| Regulation of actin cytoskeleton | |||||
| Oxytocin signaling pathway | |||||
| Gastric acid secretion | |||||
| PANTHER Pathway | Cytoskeletal regulation by Rho GTPase | ||||
| Inflammation mediated by chemokine and cytokine signaling pathway | |||||
| Pathway Interaction Database | Aurora B signaling | ||||
| PathWhiz Pathway | Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin | ||||
| Muscle/Heart Contraction | |||||
| Reactome | Smooth Muscle Contraction | ||||
| WikiPathways | Regulation of Actin Cytoskeleton | ||||
| Focal Adhesion | |||||
| Endothelin Pathways | |||||
| Muscle contraction | |||||
| MicroRNAs in cardiomyocyte hypertrophy | |||||
| References | |||||
| REF 1 | ME-3407, a new antiulcer agent, inhibits acid secretion by interfering with redistribution of H(+)-K(+)-ATPase. Am J Physiol. 1997 May;272(5 Pt 1):G1122-34. | ||||
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