Drug General Information
Drug ID	D0L6ND
Former ID	DNC010159
Drug Name	AGELADINE A
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530304]
Structure		Download 2D MOL 3D MOL
Formula	C10H7Br2N5
Canonical SMILES	C1=CN=C(C2=C1NC(=N2)N)C3=CC(=C(N3)Br)Br
InChI	1S/C10H7Br2N5/c11-4-3-6(15-9(4)12)7-8-5(1-2-14-7)16-10(13)17-8/h1-3,15H,(H3,13,16,17)
InChIKey	QAKGJAQGTQLMFN-UHFFFAOYSA-N
PubChem Compound ID	10089677
Target and Pathway
Target(s)	MMP-12	Target Info	Inhibitor	[530304]
NetPath Pathway	IL1 Signaling Pathway
	IL5 Signaling Pathway
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome	Collagen degradation
	Degradation of the extracellular matrix
WikiPathways	TGF beta Signaling Pathway
	Degradation of collagen
	Matrix Metalloproteinases
References
Ref 530304	Bioorg Med Chem Lett. 2009 Sep 15;19(18):5461-3. Epub 2009 Jul 23.Synthesis of novel ageladine A analogs showing more potent matrix metalloproteinase (MMP)-12 inhibitory activity than the natural product.
Ref 530304	Bioorg Med Chem Lett. 2009 Sep 15;19(18):5461-3. Epub 2009 Jul 23.Synthesis of novel ageladine A analogs showing more potent matrix metalloproteinase (MMP)-12 inhibitory activity than the natural product.

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