Drug Information
Drug General Information | |||||
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Drug ID |
D0L5YF
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Former ID |
DIB010867
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Drug Name |
ZD-4190
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Drug Type |
Small molecular drug
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Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Terminated | [1] | ||
Company |
AstraZeneca plc
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Structure |
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Download2D MOL |
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Formula |
C19H17BrClFN6O2
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Canonical SMILES |
c12c(Nc3c(cc(cc3)Br)F)ncnc1cc(c(c2)OC)OCCn1nncc1.Cl
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CAS Number |
CAS 257938-36-6
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | VEGF receptor | Target Info | Modulator | [2] | |
KEGG Pathway | Ras signaling pathway | ||||
Rap1 signaling pathway | |||||
Cytokine-cytokine receptor interaction | |||||
HIF-1 signaling pathway | |||||
Endocytosis | |||||
PI3K-Akt signaling pathway | |||||
Focal adhesion | |||||
Transcriptional misregulation in cancer | |||||
Rheumatoid arthritis | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009540) | ||||
REF 2 | ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy. Cancer Res. 2000 Feb 15;60(4):970-5. | ||||
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