Drug Information

Drug General Information
Drug ID
D0L5MF
Former ID
DIB005198
Drug Name
PYRAZOLOACRIDINE
Synonyms
PZA; PD-115934; 2-[3-(Dimethylamino)propyl]-9-methoxy-5-nitro-2,6-dihydropyrazolo[3,4,5-kl]acridine; 9-Methoxy-N,N-dimethyl-5-nitro-2,6-dihydropyrazolo[3,4,5-kl]acridine-2-propanamine
Drug Type
Small molecular drug
Indication Colorectal cancer [ICD9: 153, 154; ICD10:C18-C21] Phase 2 [521455]
Structure
Download
2D MOL

3D MOL
Formula
C19H21N5O3
Canonical SMILES
CN(C)CCCN1C2=C3C(=C4C=C(C=CC4=NC3=C(C=C2)[N+](=O)[O-])O<br />C)N1
InChI
1S/C19H21N5O3/c1-22(2)9-4-10-23-15-7-8-16(24(25)26)19-17(15)18(21-23)13-11-12(27-3)5-6-14(13)20-19/h5-8,11,21H,4,9-10H2,1-3H3
InChIKey
HVRZAFDJOWIDMM-UHFFFAOYSA-N
CAS Number
CAS 99009-20-8
PubChem Compound ID
5351360
PubChem Substance ID
493329, 798788, 5106348, 8137501, 11407763, 11413001, 11447219, 14901736, 37391548, 39377936, 47440973, 47811428, 50029893, 53787501, 57361365, 79749756, 103344686, 118197663, 124633467, 128134067, 128134068, 134959725, 135072101, 137560245, 140349375, 142916067, 198988612, 227137524, 232082314, 241338284, 248250635, 249923342
Target and Pathway
Target(s) DNA topoisomerase II Target Info Modulator [534593]
References
Ref 521455ClinicalTrials.gov (NCT00003802) Pyrazoloacridine in Treating Patients With Metastatic Skin or Eye Melanoma. U.S. National Institutes of Health.
Ref 534593Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II. Clin Cancer Res. 1998 Mar;4(3):683-91.

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