Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0L5JL
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| Former ID |
DIB018702
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| Drug Name |
8-cyclopentyltheophylline
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C12H16N4O2
|
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| InChI |
InChI=1S/C12H16N4O2/c1-15-10-8(11(17)16(2)12(15)18)13-9(14-10)7-5-3-4-6-7/h7H,3-6H2,1-2H3,(H,13,14)
|
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| InChIKey |
SCVHFRLUNIOSGI-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
404613, 7422376, 7422378, 7978472, 8150162, 8151340, 11110875, 11335999, 11361238, 11363245, 11365807, 11368369, 11371615, 11374259, 11376531, 11454377, 11462210, 11485544, 11489550, 11490474, 11492575, 11494165, 14774253, 17404954, 24277730, 26613177, 26679778, 26747498, 26753550, 29221108, 46500409, 47440479, 47589040, 47736529, 47810975, 48110664, 48334539, 50050395, 50106161, 50106162, 53777497, 57321066, 59775498, 78695933, 85085052, 85208930, 85230945, 85789572, 90341471, 92303920
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| Target and Pathway | |||||
| Target(s) | Adenosine A1 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | cGMP-PKG signaling pathway | ||||
| cAMP signaling pathway | |||||
| Sphingolipid signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Morphine addiction | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| RANKL Signaling Pathway | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Reactome | Adenosine P1 receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Nucleotide GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 385). | ||||
| REF 2 | Thermodynamics of full agonist, partial agonist, and antagonist binding to wild-type and mutant adenosine A1 receptors. Biochem Pharmacol. 1998 Dec 1;56(11):1437-45. | ||||
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