Drug Information

Drug General Information
Drug ID
D0L5AS
Former ID
DNC004236
Drug Name
RPR-114334
Drug Type
Small molecular drug
Indication Discovery agent Terminated [546522]
Structure
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2D MOL

3D MOL
Formula
C20H27N3O3S2
Canonical SMILES
COC(=O)C(CCSC)NC(=O)C1=CC=CC2=C1C=CC(=C2)NCC(CS)N
InChI
1S/C20H27N3O3S2/c1-26-20(25)18(8-9-28-2)23-19(24)17-5-3-4-13-10-15(6-7-16(13)17)22-11-14(21)12-27/h3-7,10,14,18,22,27H,8-9,11-12,21H2,1-2H3,(H,23,24)/t14-,18+/m1/s1
InChIKey
PXCDDWIKPOASGU-KDOFPFPSSA-N
PubChem Compound ID
10432334
Target and Pathway
Target(s) Farnesyltransferase Target Info Inhibitor [534405]
Protein farnesyltransferase beta subunit Target Info Inhibitor [534405]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-2514859:Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
Apoptotic execution phaseWP2776:Visual phototransduction
References
Ref 546522Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008739)
Ref 534405J Med Chem. 1997 Jun 6;40(12):1763-7.Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase.

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