Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0L4PY
|
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| Former ID |
DIB016349
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| Drug Name |
KB-5492
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| Drug Type |
Small molecular drug
|
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| Indication | Peptic ulcer [ICD9: 531-534; ICD10:K25-K27] | Discontinued in Phase 2 | [1] | ||
| Company |
Kanebo KK
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| Structure |
|
Download2D MOL |
|||
| Formula |
C27H34N2O10
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| Canonical SMILES |
c1(c(cc(cc1OC)CN1CCN(CC(=O)Oc2ccc(cc2)OC)CC1)OC)OC.C(=O<br />)(/C=C/C(=O)O)O
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| CAS Number |
CAS 129200-10-8
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Sigma(1)-type opioid receptor | Target Info | Antagonist | [2], [3], [4] | |
| WikiPathways | miR-targeted genes in squamous cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001141) | ||||
| REF 2 | Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6. | ||||
| REF 3 | Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. | ||||
| REF 4 | Sigma receptor-mediated effects of a new antiulcer agent, KB-5492, on experimental gastric mucosal lesions and gastric alkaline secretion in rats. J Pharmacol Exp Ther. 1994 May;269(2):799-805. | ||||
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