Drug General Information |
Drug ID |
D0L4HJ
|
Former ID |
DNC003943
|
Drug Name |
RPR-108518A
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C19H22ClN3O5
|
Canonical SMILES |
COC1=CC(=CC(=C1OC)OC)NC2=NC=NC3=CC(=C(C=C32)OC)OC.Cl
|
InChI |
1S/C19H21N3O5.ClH/c1-23-14-8-12-13(9-15(14)24-2)20-10-21-19(12)22-11-6-16(25-3)18(27-5)17(7-11)26-4;/h6-10H,1-5H3,(H,20,21,22);1H
|
InChIKey |
WMNKNJMZZZHKMH-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
Lck tyrosine kinase |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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NF-kappa B signaling pathway
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Osteoclast differentiation
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Natural killer cell mediated cytotoxicity
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T cell receptor signaling pathway
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HTLV-I infection
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Primary immunodeficiency
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NetPath Pathway
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TCR Signaling Pathway
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IL2 Signaling Pathway
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PANTHER Pathway
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Parkinson disease
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T cell activation
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Pathway Interaction Database
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Atypical NF-kappaB pathway
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Glypican 1 network
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TCR signaling in naï
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Signaling events mediated by PTP1B
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IL12-mediated signaling events
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Regulation of p38-alpha and p38-beta
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TCR signaling in naï
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Thromboxane A2 receptor signaling
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SHP2 signaling
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IL2-mediated signaling events
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CXCR4-mediated signaling events
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Class I PI3K signaling events
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IL2 signaling events mediated by PI3K
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amb2 Integrin signaling
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EPHA forward signaling
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PDGFR-beta signaling pathway
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IL2 signaling events mediated by STAT5
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Ephrin B reverse signaling
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Alpha-synuclein signaling
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Reactome
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GPVI-mediated activation cascade
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PIP3 activates AKT signaling
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Regulation of KIT signaling
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Phosphorylation of CD3 and TCR zeta chains
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Translocation of ZAP-70 to Immunological synapse
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Generation of second messenger molecules
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PECAM1 interactions
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Constitutive Signaling by Aberrant PI3K in Cancer
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DAP12 signaling
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CD28 co-stimulation
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CD28 dependent PI3K/Akt signaling
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CD28 dependent Vav1 pathway
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CTLA4 inhibitory signaling
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PD-1 signaling
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Interleukin-2 signaling
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WikiPathways
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Notch Signaling Pathway
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Interferon type I signaling pathways
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IL-2 Signaling Pathway
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Inflammatory Response Pathway
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Signaling by SCF-KIT
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DAP12 interactions
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Host Interactions of HIV factors
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PIP3 activates AKT signaling
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T-Cell Receptor and Co-stimulatory Signaling
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B Cell Receptor Signaling Pathway
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TSLP Signaling Pathway
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TCR signaling
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Costimulation by the CD28 family
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References |
REF 1 | he preparation and sar of 4-(anilino), 4-(phenoxy), and 4-(thiophenoxy)-quinazolines: Inhibitors of p56lck and EGF-R tyrosine kinase activity, Bioorg. Med. Chem. Lett. 7(4):417-420 (1997). |