Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0L3MJ
|
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| Former ID |
DIB020956
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| Drug Name |
SKF-83959
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| Synonyms |
SKF83959; SKF 83959
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C18H20ClNO2
|
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| InChI |
InChI=1S/C18H20ClNO2/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3
|
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| InChIKey |
JXMYTVOBSFOHAF-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
10243394, 14752552, 29311436, 47425387, 50065236, 50104977, 50525629, 57344557, 85209559, 90340965, 103695208, 103805509, 104118280, 104140316, 104380016, 117460295, 124750212, 124881424, 126437683, 128341787, 134223246, 135087983, 135610667, 137010205, 139740362, 179294253, 229030508, 246793511, 252166653
|
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| Target and Pathway | |||||
| Target(s) | Dopamine D1 receptor | Target Info | Agonist | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Dopaminergic synapse | |||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Morphine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Dopamine receptor mediated signaling pathway | ||||
| PathWhiz Pathway | Dopamine Activation of Neurological Reward System | ||||
| Reactome | Dopamine receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Identification of G protein-biased agonists that fail to recruit beta-arrestin or promote internalization of the D1 dopamine receptor. ACS Chem Neurosci. 2015 Apr 15;6(4):681-92. | ||||
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