Drug General Information
Drug ID	D0L3JR
Former ID	DIB013365
Drug Name	MG-516
Synonyms	Multikinase inhibitor (oral, cancer), Methylgene
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Investigative	[543499]
Company	MethylGene Inc
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Hepatocyte growth factor receptor	Target Info	Inhibitor	[543501]
	Vascular endothelial growth factor receptor 3	Target Info	Inhibitor	[543500]
	Vascular endothelial growth factor receptor 2	Target Info	Inhibitor	[543499]
	Proto-oncogene tyrosine-protein kinase receptor ret	Target Info	Inhibitor	[543572]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	Endocytosis
	PI3K-Akt signaling pathway
	Axon guidance
	Focal adhesion
	Adherens junction
	Bacterial invasion of epithelial cells
	Epithelial cell signaling in Helicobacter pylori infection
	Malaria
	Pathways in cancer
	Transcriptional misregulation in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Renal cell carcinoma
	Melanoma
	Central carbon metabolism in cancerhsa04014:Ras signaling pathway
	Focal adhesionhsa04014:Ras signaling pathway
	VEGF signaling pathway
	Proteoglycans in cancerhsa04144:Endocytosis
	Thyroid cancer
	Central carbon metabolism in cancer
NetPath Pathway	TNFalpha Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Angiogenesis
	VEGF signaling pathway
Pathway Interaction Database	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	Arf6 signaling events
	Signaling events mediated by TCPTP
	Posttranslational regulation of adherens junction stability and dissassembly
	Direct p53 effectors
	Syndecan-1-mediated signaling events
	Stabilization and expansion of the E-cadherin adherens junction
	a6b1 and a6b4 Integrin signaling
	FGF signaling pathway
	Regulation of retinoblastoma proteinvegf_vegfr_pathway:VEGF and VEGFR signaling network
	VEGFR3 signaling in lymphatic endotheliumhif2pathway:HIF-2-alpha transcription factor network
	Beta3 integrin cell surface interactions
	SHP2 signaling
	S1P1 pathway
	VEGF and VEGFR signaling network
	Integrins in angiogenesis
	Signaling events mediated by VEGFR1 and VEGFR2
	Notch-mediated HES/HEY networkret_pathway:Signaling events regulated by Ret tyrosine kinase
Reactome	Sema4D mediated inhibition of cell attachment and migrationR-HSA-195399:VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
	VEGF binds to VEGFR leading to receptor dimerization
	Integrin cell surface interactions
	EPHA-mediated growth cone collapse
	VEGFA-VEGFR2 Pathway
	VEGFR2 mediated cell proliferation
WikiPathways	TGF beta Signaling Pathway
	Signaling of Hepatocyte Growth Factor Receptor
	Focal Adhesion
	Extracellular vesicle-mediated signaling in recipient cells
	Signaling Pathways in Glioblastoma
	miR-targeted genes in squamous cell - TarBase
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	Semaphorin interactionsWP1919:Signaling by VEGFWP306:Focal Adhesion
	Nifedipine Activity
	Cardiac Progenitor Differentiation
	Signaling by VEGF
	AngiogenesisWP706:SIDS Susceptibility Pathways
	Dopaminergic Neurogenesis
References
Ref 543499	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1813).
Ref 543499	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1813).
Ref 543500	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1814).
Ref 543501	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815).
Ref 543572	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2185).

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