Drug General Information
Drug ID
D0L2IQ
Former ID
DNC000639
Drug Name
Fasidotril
Drug Type
Small molecular drug
Indication Hypotension [ICD9: 458, 796.3; ICD10:I95] Discontinued in Phase 2 [541638], [545632]
Structure
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2D MOL

3D MOL

Formula
C23H25NO6S
InChI
InChI=1S/C23H25NO6S/c1-15(23(27)28-12-17-6-4-3-5-7-17)24-22(26)19(13-31-16(2)25)10-18-8-9-20-21(11-18)30-14-29-20/h3-9,11,15,19H,10,12-14H2,1-2H3,(H,24,26)/t15-,19+/m0/s1
InChIKey
KKBIUAUSZKGNOA-HNAYVOBHSA-N
CAS Number
CAS 82059-50-5
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Neutral endopeptidase Target Info Modulator
KEGG Pathway Renin-angiotensin system
Hematopoietic cell lineage
Protein digestion and absorption
Alzheimer's disease
NetPath Pathway EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways Metabolism of Angiotensinogen to Angiotensins
Primary Focal Segmental Glomerulosclerosis FSGS
Alzheimers Disease
References
Ref 541638(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6501).
Ref 545632Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003997)

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