Drug Information

Drug General Information
Drug ID
D0L1AT
Former ID
DNC003184
Drug Name
5,10-Dideazatetrahydrofolic Acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
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2D MOL

3D MOL
Formula
C21H25N5O6
Canonical SMILES
C1C(CNC2=C1C(=O)N=C(N2)N)CCC3=CC=C(C=C3)C(=O)NC(CCC(=O)<br />O)C(=O)O
InChI
1S/C21H25N5O6/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30)/t12?,15-/m0/s1
InChIKey
ZUQBAQVRAURMCL-CVRLYYSRSA-N
PubChem Compound ID
105040
PubChem Substance ID
10233738, 14857252, 15477865, 44434579, 49972818, 50714710, 53788440, 103919004, 104373490, 127323943, 127323944, 129957500, 134339930, 134343759, 135061233, 138647652, 172919177, 180371293, 224913633, 234492230
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [551393]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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