TTD | Drug: D0L0UF

Drug General Information
Drug ID	D0L0UF
Former ID	DIB009434
Drug Name	MEN-11467
Indication	Respiratory tract inflammation [ICD10:J00-J99]		Terminated	[546840]
Company	The Menarini Group
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(C(=O)N[C@@H]2[C@H](NC(=O)[C@H](N(C(=O)Cc3ccc(cc3)C)C<br />)Cc3cc4c(cc3)cccc4)CCCC2)c[nH]c2c1cccc2
CAS Number	CAS 214487-46-4
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[525953]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546840	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010564)
Ref 525953	Effect of the long-acting tachykinin NK(1) receptor antagonist MEN 11467 on tracheal mucus secretion in allergic ferrets. Br J Pharmacol. 2001 Jan;132(1):189-96.

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Drug Information