Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0L0UF
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| Former ID |
DIB009434
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| Drug Name |
MEN-11467
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| Indication | Respiratory tract inflammation [ICD10:J00-J99] | Terminated | [1] | ||
| Company |
The Menarini Group
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1(C(=O)N[C@@H]2[C@H](NC(=O)[C@H](N(C(=O)Cc3ccc(cc3)C)C<br />)Cc3cc4c(cc3)cccc4)CCCC2)c[nH]c2c1cccc2
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| CAS Number |
CAS 214487-46-4
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| Target and Pathway | |||||
| Target(s) | Substance-P receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Measles | |||||
| PANTHER Pathway | CCKR signaling map ST | ||||
| Reactome | G alpha (q) signalling events | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Spinal Cord Injury | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010564) | ||||
| REF 2 | Effect of the long-acting tachykinin NK(1) receptor antagonist MEN 11467 on tracheal mucus secretion in allergic ferrets. Br J Pharmacol. 2001 Jan;132(1):189-96. | ||||
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