Drug General Information
Drug ID	D0L0MO
Former ID	DIB004340
Drug Name	Satigrel
Synonyms	E-5510
Drug Type	Small molecular drug
Indication	Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Discontinued in Preregistration	[544655]
Company	Eisai Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C20H19NO4
Canonical SMILES	C(=C(C#N)CCC(=O)O)(c1ccc(cc1)OC)c1ccc(cc1)OC
CAS Number	CAS 111753-73-2
PubChem Compound ID	65913
Target and Pathway
Target(s)	Thromboxane-A synthase	Target Info	Modulator	[534205]
BioCyc Pathway	C20 prostanoid biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Platelet activation
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Prostaglandin Synthesis and Regulation
	Arachidonic acid metabolism
	Phase 1 - Functionalization of compounds
	Eicosanoid Synthesis
References
Ref 544655	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000441)
Ref 534205	Mechanisms of satigrel (E5510), a new anti-platelet drug, in inhibiting human platelet aggregation. Selectivity and potency against prostaglandin H synthases isozyme activities and phosphodiesterase isoform activities. Biol Pharm Bull. 1996 Jun;19(6):828-33.

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