Drug Information

Drug General Information
Drug ID
D0KX9Z
Former ID
DIB006827
Drug Name
S-12363
Synonyms
S-12363 (liposomal, cancer); S-12363 (liposomal, cancer), Servier
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Discontinued in Phase 2 [544756]
Company
Servier
Structure
Download
2D MOL

3D MOL
Formula
C51H74N5O14PS
Canonical SMILES
[C@@]1([C@H]2[C@@]3([C@@H]4[C@]([C@H]1O)(C=CCN4CC3)CC)c<br />1c(N2C)cc(c([C@@]2(c3c(c4c([nH]3)cccc4)CCN3C[C@](CC(C2)<br />C3)(O)CC)C(=O)OC)c1)OC)(C(=O)N[C@@H](P(=O)(OCC)OCC)C(C)<br />C)O.S(=O)(=O)(O)O
CAS Number
CAS 123286-01-1
PubChem Compound ID
6918169
Target and Pathway
Target(s) Tubulin beta Target Info Modulator [550022]
KEGG Pathway Phagosome
Gap junction
Pathogenic Escherichia coli infection
NetPath Pathway FSH Signaling Pathway
TCR Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Huntington disease
Reactome Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Anchoring of the basal body to the plasma membrane
WikiPathways Parkin-Ubiquitin Proteasomal System pathway
Pathogenic Escherichia coli infection
Mitotic G2-G2/M phases
References
Ref 544756Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000879)
Ref 550022Microtubule assembly protects the region 28-38 of the beta- tubulin subunit. Article first published online: 4 FEB 2005.

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