Drug Information

Drug General Information
Drug ID
D0KX9I
Former ID
DCL000565
Drug Name
MK-0524B
Drug Type
Small molecular drug
Indication Atherosclerosis [ICD9: 414.0, 440; ICD10:I70] Discontinued in Phase 3 [548247]
Company
Merck
Structure
Download
2D MOL

3D MOL
Formula
C21H19ClFNO4S
Canonical SMILES
CS(=O)(=O)C1=C2C(=CC(=C1)F)C3=C(N2CC4=CC=C(C=C4)Cl)C(CC<br />3)CC(=O)O
InChI
1S/C21H19ClFNO4S/c1-29(27,28)18-10-15(23)9-17-16-7-4-13(8-19(25)26)20(16)24(21(17)18)11-12-2-5-14(22)6-3-12/h2-3,5-6,9-10,13H,4,7-8,11H2,1H3,(H,25,26)/t13-/m1/s1
InChIKey
NXFFJDQHYLNEJK-CYBMUJFWSA-N
PubChem Compound ID
9867642
PubChem Substance ID
14832522, 16319858, 24159188, 45289906, 79316133, 96025623, 103506442, 104083674, 125240979, 126671694, 126731356, 134339127, 134344330, 135195695, 136367874, 137185589, 139755590, 144116232, 152255074, 152258799, 152344287, 160647650, 162012049, 162205095, 163125572, 164023436, 172087022, 175266118, 178100382, 186014491, 204366771, 223398991, 223556714, 223674460, 225130865, 227246809, 247021101, 249816641, 251971100, 252451672
Target and Pathway
Target(s) 3-hydroxy-3-methylglutaryl-coenzyme A reductase Target Info Inhibitor [549718], [550977]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Mevalonate pathway
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
AMPK signaling pathway
Bile secretion
NetPath Pathway IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TSH Signaling Pathway
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
WikiPathways Statin Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Cholesterol Biosynthesis
References
Ref 548247Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023729)
Ref 549718A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-8.
Ref 550977Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs. PLoS One. 2015 May 27;10(5):e0125021. doi: 10.1371/journal.pone.0125021. eCollection 2015.

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