Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0KR3X
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| Former ID |
DIB004946
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| Drug Name |
CGS-30440
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| Indication | Hypertension [ICD9: 401; ICD10:I10-I16] | Terminated | [1] | ||
| Company |
Ciba-Geigy Corp
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
C(=O)(NC1(C(=O)N[C@H](C(=O)OCC)Cc2ccc(cc2)OC)CCCC1)[C@@<br />H](SC(=O)C)C(C)C
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| CAS Number |
CAS 169319-62-4
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| Target and Pathway | |||||
| Target(s) | Neutral endopeptidase | Target Info | Modulator | [1] | |
| Angiotensin-converting enzyme | Target Info | Modulator | [1] | ||
| KEGG Pathway | Renin-angiotensin system | ||||
| Hematopoietic cell lineage | |||||
| Protein digestion and absorption | |||||
| Alzheimer's diseasehsa04614:Renin-angiotensin system | |||||
| Chagas disease (American trypanosomiasis) | |||||
| Hypertrophic cardiomyopathy (HCM) | |||||
| NetPath Pathway | EGFR1 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | |||||
| PathWhiz Pathway | Angiotensin Metabolism | ||||
| Reactome | Metabolism of Angiotensinogen to AngiotensinsR-HSA-2022377:Metabolism of Angiotensinogen to Angiotensins | ||||
| WikiPathways | Metabolism of Angiotensinogen to Angiotensins | ||||
| Primary Focal Segmental Glomerulosclerosis FSGS | |||||
| Alzheimers DiseaseWP554:ACE Inhibitor Pathway | |||||
| References | |||||
| REF 1 | Antihypertensive and natriuretic effects of CGS 30440, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase 24.11. J Pharmacol Exp Ther. 1998 Mar;284(3):974-82. | ||||
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