| Drug General Information |
| Drug ID |
D0K9KS
|
| Former ID |
DIB008574
|
| Drug Name |
Draculin
|
| Indication |
Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]
|
Terminated |
[1]
|
|---|
| Company |
Instituto Venezolano de Investigaciones Cientificas
|
| CAS Number |
CAS 160995-22-2
|
| Target and Pathway |
| Target(s) |
Coagulation factor Xa |
Target Info |
Modulator |
[2]
|
|---|
| Coagulation factor IX |
Target Info |
Modulator |
[2]
|
|
KEGG Pathway
|
Complement and coagulation cascadeshsa04610:Complement and coagulation cascades
|
|
PANTHER Pathway
|
Blood coagulationP00011:Blood coagulation
|
|
Pathway Interaction Database
|
Beta2 integrin cell surface interactions
|
|
PathWhiz Pathway
|
CoagulationPW000562:Coagulation
|
|
Reactome
|
Extrinsic Pathway of Fibrin Clot Formation
|
|
Intrinsic Pathway of Fibrin Clot Formation
|
|
Common Pathway of Fibrin Clot Formation
|
|
Gamma-carboxylation of protein precursors
|
|
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
|
|
Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-140834:Extrinsic Pathway of Fibrin Clot Formation
|
|
Removal of aminoterminal propeptides from gamma-carboxylated proteins
|
|
WikiPathways
|
Complement and Coagulation Cascades
|
|
Human Complement System
|
|
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
|
|
Blood Clotting Cascade
|
|
Formation of Fibrin Clot (Clotting Cascade)WP558:Complement and Coagulation Cascades
|
|
Formation of Fibrin Clot (Clotting Cascade)
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004668) |
|---|
| REF 2 | Expression of biological activity of draculin, the anticoagulant factor from vampire bat saliva, is strictly dependent on the appropriate glycosylation of the native molecule. Biochim Biophys Acta. 1998 Oct 23;1425(2):291-9. |
|---|
