TTD | Drug: D0K8NO

Drug General Information
Drug ID	D0K8NO
Former ID	DIB018790
Drug Name	AK198
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533225]
Structure		Download 2D MOL
Formula	C16H14ClFN2O4
InChI	InChI=1S/C16H14ClFN2O4/c17-10-2-4-12(14(5-10)24-8-15(21)22)16(23)20-7-9-1-3-11(19)6-13(9)18/h1-6H,7-8,19H2,(H,20,23)(H,21,22)
InChIKey	GFJYPJDGRCZNDI-UHFFFAOYSA-N
PubChem Compound ID	91820714
PubChem Substance ID	252110467, 252166837
Target and Pathway
Target(s)	Aldose reductase	Target Info	Inhibitor	[533225]
BioCyc Pathway	Methylglyoxal degradation III
BioCyc Pathway	Acetone degradation I (to methylglyoxal)
KEGG Pathway	Pentose and glucuronate interconversions
	Fructose and mannose metabolism
	Galactose metabolism
	Glycerolipid metabolism
	Metabolic pathways
NetPath Pathway	IL1 Signaling Pathway
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Fructose and Mannose Degradation
	Pyruvate Metabolism
	Pterine Biosynthesis
	Glycerolipid Metabolism
	Galactose Metabolism
WikiPathways	Metapathway biotransformation
	Polyol Pathway
	Metabolism of steroid hormones and vitamin D
References
Ref 533225	The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition. ACS Chem Biol. 2015 Jul 17;10(7):1637-42.
Ref 533225	The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition. ACS Chem Biol. 2015 Jul 17;10(7):1637-42.

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Drug Information