Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0K7CG
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| Former ID |
DNC000085
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| Drug Name |
5-Fluorouracil
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| Synonyms |
5FU
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [468018] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C4H3FN2O2
|
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| InChI |
InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
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| InChIKey |
GHASVSINZRGABV-UHFFFAOYSA-N
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| CAS Number |
CAS 51-21-8
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9851, 82653, 595836, 603131, 841046, 3139714, 5132902, 5367838, 7847650, 7891022, 7978600, 8139872, 8149350, 8152156, 10524722, 11111190, 11335229, 11360468, 11363735, 11366297, 11368859, 11371368, 11374392, 11377021, 11406045, 11461440, 11484027, 11487892, 11490250, 11492372, 11494655, 11538022, 15218968, 17389875, 17405099, 22391543, 24276773, 24278439, 24871165, 24894963, 25346604, 25621761, 26611750, 26679238, 26697058, 26747342, 26747343, 26747344, 26752979, 26758708
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| ChEBI ID |
ChEBI:46345
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| SuperDrug ATC ID |
L01BC02
|
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| SuperDrug CAS ID |
cas=000051218
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| Target and Pathway | |||||
| Target(s) | Thymidylate synthase | Target Info | Inhibitor | [534992], [535857], [535884], [538032] | |
| Dihydropyrimidine dehydrogenase [NADP+] | Target Info | Inhibitor | [535468] | ||
| BioCyc Pathway | Pyrimidine deoxyribonucleotides biosynthesis from CTP | ||||
| Pyrimidine deoxyribonucleotides de novo biosynthesis | |||||
| Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis | |||||
| Superpathway of pyrimidine deoxyribonucleoside salvage | |||||
| DTMP de novo biosynthesis (mitochondrial) | |||||
| Pyrimidine deoxyribonucleosides salvagePWY-7209:Pyrimidine ribonucleosides degradation | |||||
| Thymine degradation | |||||
| Uracil degradation | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | Trans-sulfuration and one carbon metabolism | ||||
| Retinoblastoma (RB) in Cancer | |||||
| One Carbon Metabolism | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| miR-targeted genes in leukocytes - TarBase | |||||
| miR-targeted genes in epithelium - TarBase | |||||
| Metabolism of nucleotides | |||||
| Fluoropyrimidine ActivityWP1851:Metabolism of nucleotides | |||||
| Fluoropyrimidine Activity | |||||
| References | |||||
| Ref 534992 | Thymidylate synthase expression in patients with colorectal carcinoma using a polyclonal thymidylate synthase antibody in comparison to the TS 106 monoclonal antibody. J Histochem Cytochem. 2000 Jun;48(6):755-60. | ||||
| Ref 535468 | Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells. Eur J Cancer. 2002 Jun;38(9):1271-7. | ||||
| Ref 535857 | Association of gastric and intestinal phenotypic marker expression of gastric carcinomas with tumor thymidylate synthase expression and response to postoperative chemotherapy with 5-fluorouracil. J Cancer Res Clin Oncol. 2003 Dec;129(12):683-90. Epub 2003 Oct 24. | ||||
| Ref 535884 | The efficacy of the combination therapy of 5-fluorouracil, cisplatin and leucovorin for hepatocellular carcinoma and its predictable factors. Cancer Chemother Pharmacol. 2004 Apr;53(4):296-304. Epub2003 Dec 20. | ||||
| Ref 538032 | Acquisition of resistance to anticancer agents by overproduction of target enzymes. Nippon Rinsho. 1997 May;55(5):1030-7. | ||||
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