Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0K6SM
|
||||
| Former ID |
DCL000132
|
||||
| Drug Name |
Ilepatril
|
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| Indication | Hypertension; Renal failure; Heart failure; Diabetic nephropathy [ICD9: 250, 401, 428, 580-599, 584, 585; ICD10:E08-E13, I10-I16, I50, N00-N29, N17, N18, N19] | Discontinued in Phase 2/3 | [1] | ||
| Company |
Sanofi-Aventis
|
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| Structure |
|
Download2D MOL |
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| Target and Pathway | |||||
| Target(s) | Neutral endopeptidase | Target Info | Modulator | [1] | |
| Angiotensin-converting enzyme | Target Info | Modulator | [1] | ||
| KEGG Pathway | Renin-angiotensin system | ||||
| Hematopoietic cell lineage | |||||
| Protein digestion and absorption | |||||
| Alzheimer's diseasehsa04614:Renin-angiotensin system | |||||
| Chagas disease (American trypanosomiasis) | |||||
| Hypertrophic cardiomyopathy (HCM) | |||||
| NetPath Pathway | EGFR1 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | |||||
| PathWhiz Pathway | Angiotensin Metabolism | ||||
| Reactome | Metabolism of Angiotensinogen to AngiotensinsR-HSA-2022377:Metabolism of Angiotensinogen to Angiotensins | ||||
| WikiPathways | Metabolism of Angiotensinogen to Angiotensins | ||||
| Primary Focal Segmental Glomerulosclerosis FSGS | |||||
| Alzheimers DiseaseWP554:ACE Inhibitor Pathway | |||||
| References | |||||
| REF 1 | Ilepatril (AVE-7688), a vasopeptidase inhibitor for the treatment of hypertension. Curr Opin Investig Drugs. 2008 Mar;9(3):301-9. | ||||
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