Drug Information

Drug General Information
Drug ID
D0K5EE
Former ID
DIB012791
Drug Name
S-33084
Synonyms
Benzopyrano[3,4-c]pyrrole derivs, Servier
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Preclinical [538794], [547145]
Company
Servier
Structure
Download
2D MOL

3D MOL
Formula
C29H29N3O2
InChI
InChI=1S/C29H29N3O2/c30-17-21-8-13-28-26(16-21)27-19-32(18-25(27)20-34-28)15-5-4-14-31-29(33)24-11-9-23(10-12-24)22-6-2-1-3-7-22/h1-3,6-13,16,25,27H,4-5,14-15,18-20H2,(H,31,33)/t25-,27+/m1/s1
InChIKey
QQJHRQZZCNYDMX-VPUSJEBWSA-N
CAS Number
CAS 273203-30-8
PubChem Compound ID
9868452
PubChem Substance ID
14833356, 24159804, 45290716, 48256936, 49894161, 80762546, 103255977, 129060183, 134224504, 135650970, 136351772, 233018309
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Modulator [525807]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 538794(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 129).
Ref 547145Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013394)
Ref 525807S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626. J Pharmacol Exp Ther. 2000 Jun;293(3):1063-73.

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