| Drug General Information |
| Drug ID |
D0K4HW
|
| Former ID |
DNC004426
|
| Drug Name |
N-DESMETHYLCLOZAPINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Schizophrenia; Schizoaffective disorders [ICD9: 295, 295.70; ICD10:F20, F25]
|
Phase 2 |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C17H17ClN4
|
| InChI |
InChI=1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19,21H,7-10H2
|
| InChIKey |
HESZUPIXRNZIOI-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
631807, 5566057, 11113852, 14776686, 24893957, 26752025, 29221975, 32084983, 53788089, 56311660, 57321482, 79643652, 85788311, 90341107, 91612247, 92712278, 103221584, 103808667, 103858519, 104014767, 104301709, 117464490, 121361302, 125544710, 126630134, 126656816, 128300673, 134341631, 135061653, 135610864, 135650395, 135698054, 136350449, 137123192, 139649952, 141645434, 152100640, 162023011, 162221239, 162880946, 163564402, 164839413, 175612399, 179236053, 184589776, 198961388, 198991745, 224094687, 226973046, 227063804
|
| Target and Pathway |
| Target(s) |
Muscarinic acetylcholine receptor M1 |
Target Info |
Modulator |
|
|---|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
PI3K-Akt signaling pathway
|
|
Cholinergic synapse
|
|
Regulation of actin cytoskeleton
|
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PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
|
Reactome
|
Muscarinic acetylcholine receptors
|
|
G alpha (q) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
|
Calcium Regulation in the Cardiac Cell
|
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Regulation of Actin Cytoskeleton
|
|
GPCRs, Class A Rhodopsin-like
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
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Secretion of Hydrochloric Acid in Parietal Cells
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 333). |
|---|
