Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0K3LX
|
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| Former ID |
DIB016993
|
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| Drug Name |
RNAPc2
|
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| Synonyms |
RAcAPc2; Recombinant nematode anticoagulant protein, Dendreon; Recombinant nematode anticoagulant protein, Nuvelo
|
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| Indication | Colorectal cancer [ICD9: 153, 154; ICD10:C18-C21] | Discontinued in Phase 2 | [1] | ||
| Company |
Dendreon San Diego LLC
|
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| Target and Pathway | |||||
| Target(s) | Coagulation factor VII | Target Info | Modulator | [2] | |
| KEGG Pathway | Complement and coagulation cascades | ||||
| PANTHER Pathway | Angiogenesis | ||||
| Blood coagulation | |||||
| PathWhiz Pathway | Coagulation | ||||
| Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
| Extrinsic Pathway of Fibrin Clot Formation | |||||
| Gamma-carboxylation of protein precursors | |||||
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | |||||
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | |||||
| WikiPathways | Complement and Coagulation Cascades | ||||
| PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | |||||
| Blood Clotting Cascade | |||||
| Formation of Fibrin Clot (Clotting Cascade) | |||||
| Circadian Clock | |||||
| Folate Metabolism | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006762) | ||||
| REF 2 | rNAPc2 inhibits colorectal cancer in mice through tissue factor. Clin Cancer Res. 2009 Jan 1;15(1):208-16. | ||||
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