Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0K2PS
|
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| Former ID |
DIB000608
|
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| Drug Name |
Carmoxirole
|
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| Synonyms |
Carmoxirole hydrochloride; EMD-45609
|
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| Drug Type |
Small molecular drug
|
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| Indication | Hypertension [ICD9: 401; ICD10:I10-I16] | Phase 1 | [1] | ||
| Company |
Merck KGaA
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C24H26N2O2
|
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| Canonical SMILES |
c12cc(C(=O)O)ccc2[nH]cc1CCCCN1CC=C(CC1)c1ccccc1
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | D(2) dopamine receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | Rap1 signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Dopaminergic synapse | |||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Nicotine pharmacodynamics pathway | |||||
| Reactome | Dopamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| References | |||||
| REF 1 | Pharmacokinetics and first clinical experiences with an antihypertensive dopamine (DA2) agonist. Eur Heart J. 1992 Sep;13 Suppl D:121-8. | ||||
| REF 2 | Neurohumoral response to carmoxirole, a selective dopamine (D2) receptor agonist, in patients with chronic moderate heart failure. Cardiovasc Drugs Ther. 1998 Sep;12(4):387-94. | ||||
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