Drug General Information
Drug ID
D0J8ZA
Former ID
DAP000955
Drug Name
Quinethazone
Synonyms
Aquamox; Chinetazone; Chinethazone; Chinethazonum; Hydromox; Idrokin; Quinetazona; Quinethazon; Quinethazonum; Chinetazone[DCIT]; CL 36010; Hydromox (TN); Quinetazona [INN-Spanish]; Quinethazone (aquamox); Quinethazonum [INN-Latin]; Quinethazone (JAN/INN); Quinethazone [INN:BAN:JAN]; 2-Ethyl-7-chloro-1,2,3,4-tetrahydro-4-oxochinazolin-6-sulfonamid; 7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide; 7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-sulfamoylquinazoline; 7-Chloro-2-ethyl-6-sulfamoyl-1,2,3,4-tetrahydro-4-quinazolinone; 7-chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide; 7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide
Drug Type
Small molecular drug
Indication Hypertension; Congestive heart failure [ICD9: 401, 428; ICD10:I10-I16, I50] Approved [538464], [542309], [551871]
Therapeutic Class
Antihypertensive Agents
Structure
Download
2D MOL

3D MOL

Formula
C10H12ClN3O3S
InChI
InChI=1S/C10H12ClN3O3S/c1-2-9-13-7-4-6(11)8(18(12,16)17)3-5(7)10(15)14-9/h3-4,9,13H,2H2,1H3,(H,14,15)(H2,12,16,17)
InChIKey
AGMMTXLNIQSRCG-UHFFFAOYSA-N
CAS Number
CAS 73-49-4
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
C03BA02
SuperDrug CAS ID
cas=000073494
Target and Pathway
Target(s) Carbonic anhydrase Target Info Inhibitor [536672]
References
Ref 538464FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 013264.
Ref 542309(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7289).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536672Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2567-73. Epub 2008 Mar 20.

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