Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0J7EH
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| Former ID |
DCL000030
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| Drug Name |
ACCLAIM
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| Synonyms |
Depon; Excel; Furore; PUMA; Whip; Fenoxaprop ethyl; Fenoxaprop ethyl ester; Fenoxaprop ethyl ester [ANSI]; Tiller Herbicide; HOE 33171; FENOXAPROP-ETHYL; HOE-A 25-01; Ethyl 2-(4-((6-chlorobenzoxazol-2-yl)oxy)phenoxy)propionate; Ethyl 2-[4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy]propanoate; Ethyl (D+)-2-(4-(6-chlor-2-benzoxazolyloxy)phenoxy)propanoate; Ethyl (D+)-2-(4-(6-chlor-2-benzoxazolyloxy)phenoxy)propanoate [French]; Ethyl 2-(4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy)propanoate; Ethyl 2-{4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}propanoate; Ethyl-2-((4-(6-chloro-2-benzoxazolyloxy))-phenoxy)propionate; Ethyl (+-)-2-(4-(6-chloro-2-benzoxazolyloxy)phenoxy)propanoate; Propanoic acid, 2-(4-((6-chloro-2-benzoxazolyl)oxy)phenoxy)-, ethyl ester; (+/-)-2-(4-((6-Chloro-2-benzoxazolyl)oxy)phenoxy)propanoic acid ethyl ester; 2-(4-((6-Chloro-2-benzoxazolylen)oxy)phenoxy)propanoic acid, ethyl ester
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| Drug Type |
Small molecular drug
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| Indication | Angina; Coronary artery disease [ICD9: 410-414, 413, 429.2; ICD10:I20, I20-I25] | Phase 2 | [523027] | ||
| Company |
Angiogenix
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| Structure |
|
Download2D MOL |
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| Formula |
C18H16ClNO5
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| Canonical SMILES |
CCOC(=O)C(C)OC1=CC=C(C=C1)OC2=NC3=C(O2)C=C(C=C3)Cl
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| InChI |
1S/C18H16ClNO5/c1-3-22-17(21)11(2)23-13-5-7-14(8-6-13)24-18-20-15-9-4-12(19)10-16(15)25-18/h4-11H,3H2,1-2H3
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| InChIKey |
PQKBPHSEKWERTG-UHFFFAOYSA-N
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| CAS Number |
CAS 66441-23-4
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| PubChem Compound ID | |||||
| PubChem Substance ID |
13207, 6755668, 8180468, 14926007, 34712873, 47919709, 47994668, 48425882, 50022219, 50113104, 50113105, 57313163, 77630638, 92251428, 103211554, 104354210, 121279343, 124893478, 125355783, 126685344, 128953307, 131322999, 134338741, 135007684, 135013078, 137015951, 140371212, 144211483, 152035211, 162180818, 162252035, 162305047, 164756949, 175426962, 176286330, 176306152, 179316689, 184556555, 206246298, 223439687, 223678202, 226437562, 250113001, 252270257, 252369246, 252448729
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| Target and Pathway | |||||
| Target(s) | Nitric-oxide synthase, endothelial | Target Info | Stimulator | [550543] | |
| BioCyc Pathway | Citrulline-nitric oxide cycle | ||||
| NetPath Pathway | Wnt Signaling Pathway | ||||
| Pathway Interaction Database | Plasma membrane estrogen receptor signaling | ||||
| Validated transcriptional targets of AP1 family members Fra1 and Fra2 | |||||
| Angiopoietin receptor Tie2-mediated signaling | |||||
| Thromboxane A2 receptor signaling | |||||
| SHP2 signaling | |||||
| VEGFR1 specific signals | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| PAR1-mediated thrombin signaling events | |||||
| References | |||||
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