Drug Information

Drug General Information
Drug ID
D0J7CE
Former ID
DIB016480
Drug Name
CDE-6960
Synonyms
CDE-6960; Protein kinase C epsilon/theta inhibitors (inflammation); PKC epsilon/theta inhibitors (inflammation), Devgen; Protein kinase C epsilon/theta inhibitors (inflammation), Devgen
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Terminated [548364]
Company
Devgen NV
Target and Pathway
Target(s) Protein kinase C, epsilon type Target Info Inhibitor [548365]
Protein kinase C, theta type Target Info Inhibitor [548365]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Vascular smooth muscle contraction
Tight junction
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Inflammatory mediator regulation of TRP channels
Type II diabetes mellitus
MicroRNAs in cancerhsa04064:NF-kappa B signaling pathway
T cell receptor signaling pathway
Adipocytokine signaling pathway
Measles
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
T cell activation
CCKR signaling map ST
Pathway Interaction Database Endothelins
LPA receptor mediated events
TCR signaling in na&#xef
LPA4-mediated signaling events
CDC42 signaling events
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL2-mediated signaling events
PDGFR-beta signaling pathway
IL8- and CXCR1-mediated signaling events
Regulation of Ras family activation
Downstream signaling in na&#xef
Endothelins
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Reactome Effects of PIP2 hydrolysis
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling eventsR-HSA-111465:Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated NF-kB activation
G alpha (z) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Calcium Regulation in the Cardiac Cell
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Oncostatin M Signaling Pathway
miRs in Muscle Cell Differentiation
GPCR downstream signaling
Effects of PIP2 hydrolysis
Physiological and Pathological Hypertrophy of the HeartWP69:TCR Signaling Pathway
Insulin Signaling
Fc epsilon receptor (FCERI) signaling
Corticotropin-releasing hormone
Signaling Pathways in Glioblastoma
TCR signaling
Netrin-1 signaling
Apoptotic execution phase
References
Ref 548364Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025002)
Ref 548365Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025002)

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