Drug General Information
Drug ID
D0J5CX
Former ID
DCL001011
Drug Name
TAK-637
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Discontinued in Phase 2 [536580]
Company
Takeda
Structure
Download
2D MOL

3D MOL

Formula
C30H25F6N3O2
Canonical SMILES
CC1CCN2C(=C(C3=C(C2=O)N=CC=C3)C4=CC=C(C=C4)C)C(=O)N(C1)<br />CC5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F
InChI
1S/C30H25F6N3O2/c1-17-5-7-20(8-6-17)24-23-4-3-10-37-25(23)27(40)39-11-9-18(2)15-38(28(41)26(24)39)16-19-12-21(29(31,32)33)14-22(13-19)30(34,35)36/h3-8,10,12-14,18H,9,11,15-16H2,1-2H3/t18-/m1/s1
InChIKey
LDXQLWNPGRANTO-GOSISDBHSA-N
CAS Number
CAS 217185-75-6
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [536580]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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