Drug Information

Drug General Information
Drug ID
D0IQ0Z
Former ID
DCL001072
Drug Name
GSK1070916
Synonyms
GSK-1070916
Drug Type
Small molecular drug
Indication Advanced solid tumor [ICD9: 140-199; ICD10:C00-C75, C7A, C7B] Phase 1 [543084], [549088]
Company
GlaxoSmith-Kline
Structure
Download
2D MOL

3D MOL
Formula
C30H33N7O
InChI
InChI=1S/C30H33N7O/c1-6-37-19-26(28(34-37)21-10-12-23(13-11-21)32-30(38)36(4)5)24-14-15-31-29-25(24)17-27(33-29)22-9-7-8-20(16-22)18-35(2)3/h7-17,19H,6,18H2,1-5H3,(H,31,33)(H,32,38)
InChIKey
QTBWCSQGBMPECM-UHFFFAOYSA-N
PubChem Compound ID
46885626
PubChem Substance ID
103748127, 104150130, 109692758, 120907915, 125748893, 134339469, 134347882, 135315559, 135686172, 135686173, 135686194, 135686195, 136348839, 136349579, 136367710, 137130830, 139905068, 144116024, 152258884, 152344275, 160647733, 162011765, 162038111, 164194002, 165238064, 165246679, 174006386, 174531617, 177748955, 180371646, 198945210, 203088743, 223258873, 223685850, 224105858, 230247385, 242979888, 251963082, 251971181, 252166570, 252215499, 252359510, 252451734
Target and Pathway
Target(s) Aurora kinase B Target Info Modulator [530869]
Aurora protein kinase Target Info Modulator [530869]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic PrometaphaseR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
WikiPathways Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteinsWP437:EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 543084(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8358).
Ref 549088Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032133)
Ref 530869J Med Chem. 2010 May 27;53(10):3973-4001.Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase.

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