Drug General Information
Drug ID	D0I8YN
Former ID	DNC009848
Drug Name	2-(2-(2-fluorophenylamino)phenyl)acetic acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530235]
Structure		Download 2D MOL 3D MOL
Formula	C14H12FNO2
Canonical SMILES	C1=CC=C(C(=C1)CC(=O)O)NC2=CC=CC=C2F
InChI	1S/C14H12FNO2/c15-11-6-2-4-8-13(11)16-12-7-3-1-5-10(12)9-14(17)18/h1-8,16H,9H2,(H,17,18)
InChIKey	DWKOQWOOVUATNI-UHFFFAOYSA-N
PubChem Compound ID	18546352
Target and Pathway
Target(s)	Interleukin-8	Target Info	Inhibitor	[530235]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	NF-kappa B signaling pathway
	Toll-like receptor signaling pathway
	NOD-like receptor signaling pathway
	RIG-I-like receptor signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)
	Epithelial cell signaling in Helicobacter pylori infection
	Shigellosis
	Salmonella infection
	Pertussis
	Legionellosis
	Chagas disease (American trypanosomiasis)
	Malaria
	Amoebiasis
	Hepatitis C
	Hepatitis B
	Influenza A
	Pathways in cancer
	Transcriptional misregulation in cancer
	Bladder cancer
	Rheumatoid arthritis
NetPath Pathway	IL-7 Signaling Pathway
	IL5 Signaling Pathway
	IL1 Signaling Pathway
	TSH Signaling Pathway
	IL2 Signaling Pathway
	IL3 Signaling Pathway
	IL4 Signaling Pathway
	TNFalpha Signaling Pathway
	TSLP Signaling Pathway
	TCR Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
	Interleukin signaling pathway
	CCKR signaling map ST
Pathway Interaction Database	LPA receptor mediated events
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Glucocorticoid receptor regulatory network
	ATF-2 transcription factor network
	IL8-mediated signaling events
	AP-1 transcription factor network
	IL8- and CXCR2-mediated signaling events
	Regulation of nuclear beta catenin signaling and target gene transcription
	Syndecan-2-mediated signaling events
	Syndecan-3-mediated signaling events
	IL8- and CXCR1-mediated signaling events
Reactome	Senescence-Associated Secretory Phenotype (SASP)
	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	ATF4 activates genes
	G alpha (i) signalling events
WikiPathways	Toll-like receptor signaling pathway
	SIDS Susceptibility Pathways
	Senescence and Autophagy in Cancer
	IL-3 Signaling Pathway
	Bladder Cancer
	Activation of Genes by ATF4
	EBV LMP1 signaling
	Spinal Cord Injury
	Corticotropin-releasing hormone
	Allograft Rejection
	TSLP Signaling Pathway
	GPCR ligand binding
	GPCR downstream signaling
	Regulation of toll-like receptor signaling pathway
References
Ref 530235	Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.
Ref 530235	Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.

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