Drug Information

Drug General Information
Drug ID
D0I8DW
Former ID
DNC006642
Drug Name
4-nitrophenylsulfamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528233]
Structure
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2D MOL

3D MOL
Formula
C6H7N3O4S
Canonical SMILES
C1=CC(=CC=C1NS(=O)(=O)N)[N+](=O)[O-]
InChI
1S/C6H7N3O4S/c7-14(12,13)8-5-1-3-6(4-2-5)9(10)11/h1-4,8H,(H2,7,12,13)
InChIKey
RAXPQAODVUNKFW-UHFFFAOYSA-N
PubChem Compound ID
612414
Target and Pathway
Target(s) Carbonic anhydrase II Target Info Inhibitor [528233]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 528233J Med Chem. 2006 Jun 15;49(12):3496-500.Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements.
Ref 528233J Med Chem. 2006 Jun 15;49(12):3496-500.Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements.

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