Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0I7MT
|
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| Former ID |
DIB014224
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| Drug Name |
Puerarin
|
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| Synonyms |
NPI-031-G; Puerarin (oral formulation, alcoholism); Puerarin (oral formulation, alcoholism), Natural Pharmacia; 5-HT2creceptor antagonists/GABA receptor antagonists (oral formulation, alcoholism), Natural Pharmacia
|
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| Drug Type |
Small molecular drug
|
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| Indication | Alcohol use disorders [ICD9: 303; ICD10:F10.2] | Phase 2 | [1] | ||
| Company |
Natural Pharmacia International Inc
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C21H20O9
|
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| Canonical SMILES |
c12c([C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)c(ccc1c<br />(=O)c(co2)c1ccc(cc1)O)O
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 2C receptor | Target Info | Modulator | ||
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Serotonergic synapse | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | 5HT2 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00854724) Puerarin Effects on Alcohol Drinking. U.S. National Institutes of Health. | ||||
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