Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0I6UU
|
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| Former ID |
DIB003540
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| Drug Name |
UK-74505
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| Drug Type |
Small molecular drug
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| Indication | Septic shock [ICD9: 785.52; ICD10:A41.9] | Discontinued in Phase 2 | [1] | ||
| Company |
Pfizer Ltd
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| Structure |
|
Download2D MOL |
|||
| Formula |
C34H29ClN6O3
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| Canonical SMILES |
C1(=C(NC(=C(C1c1c(Cl)cccc1)C(=O)Nc1ncccc1)C)c1ccc(n2c(n<br />c3c2ccnc3)C)cc1)C(=O)OCC
|
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| CAS Number |
CAS 122956-68-7
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001719) | ||||
| REF 2 | Differential effects of the PAF receptor antagonist UK-74,505 on neutrophil and eosinophil accumulation in guinea-pig skin. Br J Pharmacol. 1994 Oct;113(2):513-21. | ||||
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