Drug Information

Drug General Information
Drug ID
D0I5XO
Former ID
DNC000115
Drug Name
9-Nitrocamptothecin (9-NC)
Drug Type
Small molecular drug
Indication Discovery agent Phase 2 [521755]
Structure
Download
2D MOL

3D MOL
Formula
C20H15N3O6
Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC=C(C5=C4)[N<br />+](=O)[O-])O
InChI
1S/C20H15N3O6/c1-2-20(26)13-7-16-17-10(8-22(16)18(24)12(13)9-29-19(20)25)6-11-14(21-17)4-3-5-15(11)23(27)28/h3-7,26H,2,8-9H2,1H3/t20-/m0/s1
InChIKey
VHXNKPBCCMUMSW-FQEVSTJZSA-N
CAS Number
CAS 51-45-6
PubChem Compound ID
472335
PubChem Substance ID
627908, 10307196, 12015077, 14780873, 14927821, 17398012, 50113013, 53790631, 57405623, 71821546, 80209304, 87560509, 91615946, 92712504, 99373551, 103278806, 103810112, 109758379, 117383600, 118843671, 124893436, 124893437, 126625534, 126656659, 129477592, 137139617, 141857438, 144206150, 152034751, 160809181, 162181197, 162248509, 162264173, 163087962, 164814772, 172860894, 174531449, 179116969, 196105997, 198952523, 204380899, 223484460, 223554916, 223703151, 226399789, 241175745, 249716917, 249855774, 251912149, 251915222
ChEBI ID
ChEBI:18295
SuperDrug ATC ID
V04CG03
SuperDrug CAS ID
cas=000051456
Target and Pathway
Target(s) DNA topoisomerase I Target Info Inducer [535637]
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 521755ClinicalTrials.gov (NCT00250068) Study of Aerosolized Liposomal 9-Nitro-20 (S)- Camptothecin (L9NC). U.S. National Institutes of Health.
Ref 535637A Phase I study of 9-nitrocamptothecin given concurrently with capecitabine in patients with refractory, metastatic solid tumors. Cancer. 2003 Jan 1;97(1):148-54.

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