Drug Information

Drug General Information
Drug ID
D0I5QZ
Former ID
DNC005874
Drug Name
SQ-26332
Synonyms
SQ-28603
Drug Type
Small molecular drug
Indication Discovery agent Terminated [544625]
Structure
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2D MOL

3D MOL
Formula
C17H22N2O4S
Canonical SMILES
CC(C(=O)N1CCCC1C(=O)O)NC(=O)C(CC2=CC=CC=C2)S
InChI
1S/C17H22N2O4S/c1-11(16(21)19-9-5-8-13(19)17(22)23)18-15(20)14(24)10-12-6-3-2-4-7-12/h2-4,6-7,11,13-14,24H,5,8-10H2,1H3,(H,18,20)(H,22,23)/t11-,13-,14-/m0/s1
InChIKey
YSFYVNRABGRTNY-UBHSHLNASA-N
PubChem Compound ID
9998020
Target and Pathway
Target(s) Neutral endopeptidase Target Info Inhibitor [527799]
Angiotensin-converting enzyme Target Info Inhibitor [527799]
KEGG Pathway Renin-angiotensin system
Hematopoietic cell lineage
Protein digestion and absorption
Alzheimer's diseasehsa04614:Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
NetPath Pathway EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to AngiotensinsR-HSA-2022377:Metabolism of Angiotensinogen to Angiotensins
WikiPathways Metabolism of Angiotensinogen to Angiotensins
Primary Focal Segmental Glomerulosclerosis FSGS
Alzheimers DiseaseWP554:ACE Inhibitor Pathway
References
Ref 544625Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000347)
Ref 527799J Med Chem. 2005 Oct 20;48(21):6523-43.Designed multiple ligands. An emerging drug discovery paradigm.

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