Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0I5QZ
|
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| Former ID |
DNC005874
|
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| Drug Name |
SQ-26332
|
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| Synonyms |
SQ-28603
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Terminated | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C17H22N2O4S
|
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| Canonical SMILES |
CC(C(=O)N1CCCC1C(=O)O)NC(=O)C(CC2=CC=CC=C2)S
|
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| InChI |
1S/C17H22N2O4S/c1-11(16(21)19-9-5-8-13(19)17(22)23)18-15(20)14(24)10-12-6-3-2-4-7-12/h2-4,6-7,11,13-14,24H,5,8-10H2,1H3,(H,18,20)(H,22,23)/t11-,13-,14-/m0/s1
|
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| InChIKey |
YSFYVNRABGRTNY-UBHSHLNASA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Neutral endopeptidase | Target Info | Inhibitor | [2] | |
| Angiotensin-converting enzyme | Target Info | Inhibitor | [2] | ||
| KEGG Pathway | Renin-angiotensin system | ||||
| Hematopoietic cell lineage | |||||
| Protein digestion and absorption | |||||
| Alzheimer's diseasehsa04614:Renin-angiotensin system | |||||
| Chagas disease (American trypanosomiasis) | |||||
| Hypertrophic cardiomyopathy (HCM) | |||||
| NetPath Pathway | EGFR1 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | |||||
| PathWhiz Pathway | Angiotensin Metabolism | ||||
| Reactome | Metabolism of Angiotensinogen to AngiotensinsR-HSA-2022377:Metabolism of Angiotensinogen to Angiotensins | ||||
| WikiPathways | Metabolism of Angiotensinogen to Angiotensins | ||||
| Primary Focal Segmental Glomerulosclerosis FSGS | |||||
| Alzheimers DiseaseWP554:ACE Inhibitor Pathway | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000347) | ||||
| REF 2 | J Med Chem. 2005 Oct 20;48(21):6523-43.Designed multiple ligands. An emerging drug discovery paradigm. | ||||
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