Drug General Information
Drug ID	D0I2KW
Former ID	DNC006072
Drug Name	FV-Aib-TDVGPFAF
Synonyms	[Aib29,Asp31,Pro34,Phe35]CGRP(27-37)
Indication	Discovery agent		Investigative	[529839]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Calcitonin gene-related peptide 1	Target Info	Inhibitor	[529839]
	Calcitoningene-related peptide type 1 receptor	Target Info	Inhibitor	[527974]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
Reactome	G alpha (s) signalling events
	Calcitonin-like ligand receptorsR-HSA-418555:G alpha (s) signalling events
	Calcitonin-like ligand receptors
WikiPathways	Myometrial Relaxation and Contraction Pathways
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signalingWP334:GPCRs, Class B Secretin-like
	GPCR downstream signaling
References
Ref 529839	J Med Chem. 2008 Dec 25;51(24):7889-97.Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.
Ref 527974	J Med Chem. 2006 Jan 26;49(2):616-24.Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor.
Ref 529839	J Med Chem. 2008 Dec 25;51(24):7889-97.Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.

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