| Drug General Information |
| Drug ID |
D0I1EP
|
| Former ID |
DIB020449
|
| Drug Name |
MRS928
|
| Synonyms |
galangin trimethyl ether
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H16O5
|
| InChI |
InChI=1S/C18H16O5/c1-20-12-9-13(21-2)15-14(10-12)23-17(18(22-3)16(15)19)11-7-5-4-6-8-11/h4-10H,1-3H3
|
| InChIKey |
CBTHKWVPSIGKMI-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
12231, 4789230, 10237774, 14999475, 29299004, 47359796, 47434753, 50113887, 75019354, 85295315, 85842715, 103126283, 103273649, 103979738, 104404423, 117590617, 126433994, 127601894, 134341603, 135075804, 135650667, 163110847, 175611515, 179230599, 223439785, 225068565, 227851943, 241047187, 250118206
|
| Target and Pathway |
| Target(s) |
Adenosine A3 receptor |
Target Info |
Antagonist |
[2]
|
|---|
| Adenosine A2b receptor |
Target Info |
Antagonist |
[2]
|
| Adenosine A1 receptor |
Target Info |
Antagonist |
[2]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Vascular smooth muscle contraction
|
|
Alcoholismhsa04022:cGMP-PKG signaling pathway
|
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cAMP signaling pathway
|
|
Sphingolipid signaling pathway
|
|
Morphine addiction
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
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TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
|
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RANKL Signaling Pathway
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Pathway Interaction Database
|
C-MYB transcription factor network
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Reactome
|
Adenosine P1 receptors
|
|
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
|
|
G alpha (s) signalling events
|
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Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Nucleotide GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
GPCRs, OtherWP80:Nucleotide GPCRs
|
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GPCR ligand binding
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GPCR downstream signalingWP80:Nucleotide GPCRs
|
|
GPCR downstream signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 402). |
|---|
| REF 2 | J Med Chem. 1996 Jun 7;39(12):2293-301.Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. |
|---|
