Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0I0UE
|
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| Former ID |
DNC000875
|
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| Drug Name |
Lexipafant
|
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| Drug Type |
Small molecular drug
|
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| Indication | Nerve injury [ICD10:T14.4] | Phase 2 | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C23H30N4O4S
|
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| Canonical SMILES |
CCOC(=O)C(CC(C)C)N(C)S(=O)(=O)C1=CC=C(C=C1)CN2C(=NC3=C2<br />C=CN=C3)C
|
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| InChI |
1S/C23H30N4O4S/c1-6-31-23(28)22(13-16(2)3)26(5)32(29,30)19-9-7-18(8-10-19)15-27-17(4)25-20-14-24-12-11-21(20)27/h7-12,14,16,22H,6,13,15H2,1-5H3/t22-/m0/s1
|
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| InChIKey |
AQRXDPFOYJSPMP-QFIPXVFZSA-N
|
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| CAS Number |
CAS 139133-26-9
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Modulator | ||
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Randomized, double-blind phase II trial of Lexipafant, a platelet-activating factor antagonist, in human acute pancreatitis. Br J Surg. 1995 Oct;82(10):1414-20. | ||||
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