Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0HZ2A
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| Former ID |
DIB008833
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| Drug Name |
Recombinant factor VIIa PEGylated liposomal
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| Synonyms |
Recombinant factor VIIa; Recombinant factor VIIa (PEGylated liposomal (NecLip), Hemophilia A) Recoly
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| Indication | Factor VII deficiency [ICD10:D68] | Phase 1/2 | [1] | ||
| Company |
Recoly NV
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| Target and Pathway | |||||
| Target(s) | Coagulation factor VII | Target Info | Modulator | [2] | |
| KEGG Pathway | Complement and coagulation cascades | ||||
| PANTHER Pathway | Angiogenesis | ||||
| Blood coagulation | |||||
| PathWhiz Pathway | Coagulation | ||||
| Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
| Extrinsic Pathway of Fibrin Clot Formation | |||||
| Gamma-carboxylation of protein precursors | |||||
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | |||||
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | |||||
| WikiPathways | Complement and Coagulation Cascades | ||||
| PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | |||||
| Blood Clotting Cascade | |||||
| Formation of Fibrin Clot (Clotting Cascade) | |||||
| Circadian Clock | |||||
| Folate Metabolism | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | Safety, pharmacokinetics and efficacy of factor VIIa formulated with PEGylated liposomes in haemophilia A patients with inhibitors to factor VIII--an open label, exploratory, cross-over, phase I/II study. Haemophilia. 2010 Nov;16(6):910-8. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2363). | ||||
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