Drug Information

Drug General Information
Drug ID
D0HQ0E
Former ID
DIB020974
Drug Name
spiradoline
Synonyms
U62066; U-62066; U 62066
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539023]
Structure
Download
2D MOL
Formula
C22H30Cl2N2O2
InChI
InChI=1S/C22H30Cl2N2O2/c1-25(21(27)14-16-5-6-17(23)18(24)13-16)19-7-9-22(8-4-12-28-22)15-20(19)26-10-2-3-11-26/h5-6,13,19-20H,2-4,7-12,14-15H2,1H3/t19-,20-,22-/m0/s1
InChIKey
NYKCGQQJNVPOLU-ONTIZHBOSA-N
PubChem Compound ID
55652
PubChem Substance ID
7980646, 8184266, 14782784, 14807251, 43113609, 47734234, 50065337, 57313772, 80629975, 103269962, 103915325, 104308141, 134221791, 135049549, 135651291, 135812295, 137249414, 141191317, 144206611, 170466255, 179151349, 198962017, 226612755, 252658631
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Agonist [534018]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539023(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1653).
Ref 534018Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6736-40.

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