Drug Information

Drug General Information
Drug ID
D0HK7R
Former ID
DIB012734
Drug Name
Midafotel
Synonyms
EAA-494; D-CPP-ene; SDZ-EAA-494
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Discontinued in Phase 3 [545291]
Company
BTG plc
Structure
Download
2D MOL

3D MOL
Formula
C8H15N2O5P
Canonical SMILES
P(=O)(/C=C/CN1C[C@H](C(=O)O)NCC1)(O)O
CAS Number
CAS 117414-74-1
PubChem Compound ID
6435801
Target and Pathway
Target(s) NMDA receptor Target Info Modulator [531509]
References
Ref 545291Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002722)
Ref 531509D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci Lett. 1990 Jun 8;113(3):315-21.

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