Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0HJ9U
|
||||
| Former ID |
DIB011472
|
||||
| Drug Name |
LAU-0901
|
||||
| Synonyms |
PAF receptor antagonist (brain ischemia/ corneal disease), Louisiana State University; Platelet-activating factor receptor antagonist (brain ischemia/ corneal disease), Louisiana State University
|
||||
| Indication | Brain ischaemia [ICD9: 435, 437; ICD10:G45.9, I67.8] | Investigative | [1], [2] | ||
| Company |
Louisiana State University
|
||||
| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
C1(=C(C(C(=C(N1)C)C(=O)OCCOc1ccc(c(c1)Cl)Cl)C)C(=O)OC(C<br />N1CCOCC1)CN1CCOCC1)C.Cl.Cl
|
||||
| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Antagonist | [1], [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. Exp Neurol. 2008 Dec;214(2):253-8. | ||||
| REF 2 | Superior Neuroprotective Efficacy of LAU-0901, a Novel Platelet-Activating Factor Antagonist, in Experimental Stroke. Transl Stroke Res. 2012 Mar;3(1):154-63. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.