Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0HE9J
|
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| Former ID |
DIB002919
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| Drug Name |
APN-201
|
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| Synonyms |
Lipoxysan; Liposomal SOD (wound healing), Polymun; Liposomal SOD (Peyronie's disease), Polymun; RhSOD (liposomal, dermatitis), Apeiron; Liposomal superoxide dismutase (recombinant, encapsulated, topical), Polymun
|
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| Indication | Dermatitis [ICD9: 692.9; ICD10:L20-L30] | Phase 1/2 | [1] | ||
| Company |
Polymun Scientific Immunobiologische Forschung GmbH
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| Target and Pathway | |||||
| Target(s) | Superoxide dismutase [Cu-Zn] | Target Info | Modulator | [2] | |
| BioCyc Pathway | Reactive oxygen species degradation | ||||
| KEGG Pathway | Peroxisome | ||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Huntington's disease | |||||
| Prion diseases | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| Pathway Interaction Database | Validated nuclear estrogen receptor alpha network | ||||
| FOXA1 transcription factor network | |||||
| PathWhiz Pathway | Degradation of Superoxides | ||||
| Reactome | Platelet degranulation | ||||
| Detoxification of Reactive Oxygen Species | |||||
| WikiPathways | Oxidative Stress | ||||
| Copper homeostasis | |||||
| Detoxification of Reactive Oxygen Species | |||||
| Nifedipine Activity | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Dopamine metabolism | |||||
| AGE/RAGE pathway | |||||
| Folate Metabolism | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01513278) Study of APN201 (Liposomal Recombinant Human Cu/Zn-Superoxide Dismutase) for the Prevention of Radiation-induced Dermatitis in Women With Breast Cancer. U.S. NationalInstitutes of Health. | ||||
| REF 2 | Peyronie's disease: a critical appraisal of current diagnosis and treatment. Int J Impot Res. 2008 Sep-Oct;20(5):445-59. doi: 10.1038/ijir.2008.30. Epub 2008 Jul 24. | ||||
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