TTD | Drug: D0H8XQ

Drug General Information
Drug ID	D0H8XQ
Former ID	DIB018921
Drug Name	AZ12216052
Synonyms	AZ 12216052; AZ-12216052
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541385]
Structure		Download 2D MOL
Formula	C19H22BrNOS
InChI	InChI=1S/C19H22BrNOS/c1-3-14(2)16-6-10-18(11-7-16)21-19(22)13-23-12-15-4-8-17(20)9-5-15/h4-11,14H,3,12-13H2,1-2H3,(H,21,22)
InChIKey	QKUYZJOTWYRWNF-UHFFFAOYSA-N
PubChem Compound ID	73755190
PubChem Substance ID	178102837, 249896001, 252158398, 252160415
Target and Pathway
Target(s)	Metabotropic glutamate receptor 8	Target Info	Modulator (allosteric modulator)	[530848]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Glutamatergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
Reactome	G alpha (i) signalling events
Reactome	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 541385	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6216).
Ref 530848	Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav Brain Res. 2010 Oct 15;212(2):168-73.

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Drug Information