Drug Information

Drug General Information
Drug ID
D0H8OH
Former ID
DIB014142
Drug Name
Palovarotene
Synonyms
R-667; RG-667; Retinoid receptor agonist, Roche; Ro-3300074; Ro-330074
Drug Type
Small molecular drug
Indication Emphysema [ICD9: 492; ICD10:J43] Phase 2 [531773], [543031]
Company
Roche
Structure
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2D MOL

3D MOL
Formula
C27H30N2O2
InChI
InChI=1S/C27H30N2O2/c1-26(2)12-13-27(3,4)24-17-22(18-29-15-5-14-28-29)21(16-23(24)26)11-8-19-6-9-20(10-7-19)25(30)31/h5-11,14-17H,12-13,18H2,1-4H3,(H,30,31)/b11-8+
InChIKey
YTFHCXIPDIHOIA-DHZHZOJOSA-N
CAS Number
CAS 410528-02-8
PubChem Compound ID
10295295
Target and Pathway
Target(s) Retinoic acid receptor gamma Target Info Agonist [531773]
Reactome Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Nuclear Receptors in Lipid Metabolism and Toxicity
Mesodermal Commitment Pathway
Endoderm Differentiation
Nuclear Receptors
References
Ref 531773Randomised controlled trial for emphysema with a selective agonist of the gamma-type retinoic acid receptor. Eur Respir J. 2012 Aug;40(2):306-12.
Ref 543031(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8276).
Ref 531773Randomised controlled trial for emphysema with a selective agonist of the gamma-type retinoic acid receptor. Eur Respir J. 2012 Aug;40(2):306-12.

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