Drug Information
Drug General Information | |||||
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Drug ID |
D0H7AC
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Former ID |
DCL001076
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Drug Name |
PF-03814735
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Drug Type |
Small molecular drug
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Indication | Advanced solid tumor [ICD9: 140-199; ICD10:C00-C75, C7A, C7B] | Discontinued in Phase 1 | [1] | ||
Company |
Pfizer
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Structure |
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Download2D MOL |
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Formula |
C23H25F3N6O2
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Canonical SMILES |
CC(=O)NCC(=O)N1C2CCC1C3=C2C=CC(=C3)NC4=NC=C(C(=N4)NC5CC<br />C5)C(F)(F)F
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InChI |
1S/C23H25F3N6O2/c1-12(33)27-11-20(34)32-18-7-8-19(32)16-9-14(5-6-15(16)18)30-22-28-10-17(23(24,25)26)21(31-22)29-13-3-2-4-13/h5-6,9-10,13,18-19H,2-4,7-8,11H2,1H3,(H,27,33)(H2,28,29,30,31)
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InChIKey |
RYYNGWLOYLRZLK-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Aurora kinase A | Target Info | Inhibitor | [2] | |
Aurora kinase B | Target Info | Inhibitor | [2] | ||
KEGG Pathway | Oocyte meiosis | ||||
Pathway Interaction Database | Aurora B signaling | ||||
Signaling by Aurora kinases | |||||
Integrin-linked kinase signaling | |||||
PLK1 signaling events | |||||
Aurora A signalingaurora_b_pathway:Aurora B signaling | |||||
Aurora C signaling | |||||
FOXM1 transcription factor network | |||||
Aurora A signaling | |||||
Reactome | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | ||||
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | |||||
Separation of Sister Chromatids | |||||
Resolution of Sister Chromatid Cohesion | |||||
RHO GTPases Activate Formins | |||||
Mitotic Prometaphase | |||||
WikiPathways | EGF/EGFR Signaling Pathway | ||||
JAK/STAT | |||||
Gastric Cancer Network 1 | |||||
Integrated Breast Cancer Pathway | |||||
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase | |||||
Mitotic Prometaphase | |||||
Regulation of Microtubule Cytoskeleton | |||||
miR-targeted genes in lymphocytes - TarBase | |||||
miR-targeted genes in epithelium - TarBase | |||||
APC/C-mediated degradation of cell cycle proteins | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025628) | ||||
REF 2 | Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. | ||||
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